Aifm1 CLIA Kit for Mouse(Mus musculus) | EIAab.comAifm1 CLIA Kit for Mouse(Mus musculus)

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Aifm1 (Gene name),

Apoptosis-inducing factor 1, mitochondrial (Protein name ), AIFM1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aifm1(Aif;Pdcd8);

Protein name:

Apoptosis-inducing factor 1, mitochondrial;

Alternative:

Programmed cell death protein 8;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with XIAP. Interacts (via N-terminus) with EIF3G (via C-terminus).

Function:

Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Subcellular Location:

Mitochondrion intermembrane space Mitochondrion inner membrane Cytoplasm Cytoplasm perinuclear region Nucleus Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.

Protein Attributes:

Sequence length:

612

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

612:

NEVAKLFNIH | ED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9Z0X1

Pfam:

PF00070

STRING:

10090.ENSMUSP00000041104

UniGene:

Mm.240434

SMR:

Q9Z0X1

KEGG:

mmu:26926

Uniprot:

Q9Z0X1

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ELISA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064h

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96T

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ELISA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064r

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96T

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ELISA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064m

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CLIA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Apoptosis-inducing factor 1, mitochondrial

Protein for Mouse Apoptosis-inducing factor 1, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular characterization of mitochondrial apoptosis-inducing factor."
Susin S.A. , Lorenzo H.K. , Zamzami N. , Marzo I. , Snow B.E. , Brothers G.M. , Mangion J. , Jacotot E. , Costantini P. , Loeffler M. , Larochette N. , Goodlett D.R. , Aebersold R. , Siderovski D.P. , Penninger J.M. , Kroemer G.
Nature397:441-446(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF N-TERMINUS;PROTEIN SEQUENCE OF 322-336;FUNCTION;COFACTOR;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary gland.
3.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 378-386;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
4.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
5.

"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-387 AND LYS-592;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
6.

"The crystal structure of the mouse apoptosis-inducing factor AIF."
Mate M.J. , Ortiz-Lombardia M. , Boitel B. , Haouz A. , Tello D. , Susin S.A. , Penninger J. , Kroemer G. , Alzari P.M.
Nat. Struct. Biol.9:442-446(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 108-610 IN COMPLEX WITH FAD;NAD-BINDING;MUTAGENESIS OF LYS-176 AND GLU-313

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